吕伟 教授职称: 直属机构: 化学与分子工程学院 学科: |
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教育经历1988.7-1992.7 大连理工大学 化工学院 工学学士 1992.9-1995.7 大连理工大学 化工学院 工学硕士 1995.9-1998.7 中国科学院上海药物研究所 理学博士 工作经历1998.8-1999.8 威斯康星大学 药学院 研究助理 1999.9-2001.12 中国科学院上海药物研究所 副研究员 课题组长 2002.1-2005.6 中国科学院上海药物研究所 研究员 课题组长 2005.7-至今 华东师范大学 研究员 2024年药学学科研究生招生: 华东师范大学药学学科(100700药学)自2024年深化一级学科招生、命题,包含四个研究方向:药物化学、药理学、药剂学、人工智能药物设计学。按照药学一级学科划定复试分数线。 初试科目变化(重要) 2024年药学一级学科的考试科目将由2023年的“药学专业综合”调整为“药学基础综合”,具体包括有机化学和生物化学两部分内容,各占150分,总分300分 实验室招收相关专业的博士后及研究助理 个人简介研究组成员介绍: 吕伟教授: 从事抗肿瘤药物研究,目前研究方向主要集中于新型给药体系的建立,包括抗体药物偶联物(ADC)给药体系、蛋白嵌合降解(PROTAC)体系、特异性前药、微型药物药物偶联物给药体系。已发表研究论文170多篇,获得发明专利授权30多项。2006年入选教育部新世纪人才计划,2001年入选上海市科技启明星计划。 成员介绍:
金嵇煜 副研究员
朱书雷 药学院 副教授
李亚龙 2022级硕博生
曹玉婷 2020级硕博生 丁梦园 2021级硕博生 李晓梅 2021级博士生 陈泰文 2023级博士生
王星 2023级生物与医药博士生 李旭卓 2021级硕士生 张丰旗 2021级硕士生 陆莹馨 2022级硕博生 (和余家会教授联合培养)
陈明 2022级硕士生 任倩龙 2022级硕士生 苗玉玲 2023级硕士生 白礼哲 2023级硕士生 已毕业学生 博士:丁红霞(2006) 高河勇(2006) 罗宇(2007) 李云飞(2007) 黄维刚(2007) 肖锋(2009) 张仰明(2009) 余善宝(2011) 张梅(2012) 顾明(2012) 丰祥军(2013) 陈太杰(2013) 张翾(2014) 唐开勇(2015) 王磊(2016), 鲍彬(2017) 金沉(2017) 张秋萌(2017) 金稽煜(2018) 祝奇文(2018) 车锐(2018) 刘艺(2019) 肖栋槐(2020) 朱书雷(2020) 程祉扬(2022) 硕士:阳海(2002) 蒋映艳(2003) 梅玉华(2008) 薛亚东(2009) 陈艳(2009) 刘郝敏(2010) 姚佳萍(2010) 夏文品(2010) 刘海艳(2011) 张丽娟(2011) 袁薇(2012) 宋阳(2012) 梅铁文(2013) 黄颖(2013) 刘新桂(2014) 史培忠(2014) 叶智华(2014) 刘雅倩(2015) 于秀华(2015) 潘雯(2015) 陈世光(2016) 马陇君(2016) 喻杰(2017) 李娇(2017) 文帅(2017) 刘双喜(2018) 余旭勐(2019) 颜幸佳(2019) 邵平譞(2020) 甄臻(2021) 周帅(2021) 何婷婷(2023) 2023年6月 课题组大连-烟台研学 社会兼职研究方向酶活前药系统 新一代抗体偶联药物 2023年硕士研究生招生专业:药物化学,生物与医药工程专业硕士 2023年博士研究生招生专业:有机化学(药物化学方向),生物与医药工程博士 实验室招收相关专业的博士后及研究助理 招生与培养开授课程抗肿瘤药物 科研项目主持的科研项目
在研项目: 在研各类项目7项,实验室研究经费充足。
已结题项目: 1. 学科交叉推进项目,新型抗体药物偶联物候选新药的确立和研发,202001-202112 2. 中科院干旱植物重点实验室开放课题,含苯硼酸的一枝蒿酮酸的设计合成及抗病毒活性研究,201801-202012 3. 精细化工国家重点实验开放课题,类药性近红外染料的设计及其在药物传递中的应用,201601-201812 4. 新疆特有药用资源利用实验室开放课题,难溶性天然药物的靶向给药系统研究,201511-201611 5. 国家自然科学基金项目,81172936,基于结构多样性合成策略进行天然产物结构改造及抗肿瘤药物发现,201201-201512 6. 华东师范大学科研创新基金,基于天然产物结构多样性合成策略进行抗肿瘤药物发现,200911-201112 7. 上海市科委重点公关项目,054319902,新型抗肿瘤药物的研究和开发,200511-200712 8. 国家自然科学基金项目,30572232,新型磷酸酯酶cdc25抑制剂研究,200601-200812 9. 教育部新世纪优秀人才项目,200701-200912 10.上海市科委重点公关项目,044319216,一类新药拓扑异构酶I抑制剂chimmitecan的临床前研究,200410-2006.12 11.国家863课题,2003AA2Z3531,喜树碱类抗肿瘤靶向前药的研究,200304-200512 12.中国科学院重要方向课题,KSCX2-3-07-02,以磷酸酶cdc25为靶点发展新型抗肿瘤药物,2001-2003 13.上海市科技启明星项目,01QB14047,拓扑异构酶抑制剂类抗肿瘤药物的研究,200108 14.国家自然科学基金项目,20002005,丹参二帖邻醌类抗肿瘤化合物的研究,200101-200312 15.企业合作和科技成果转化项目总计30项。 学术成果近期论文: 1. Synthesis and biological evaluation of novel quaternary ammonium antibody drug conjugates based on camptothecin derivatives, PLoS ONE, 2023, 18(12): e0292871 2. Development of HSP90 inhibitors-SN38 conjugates for cancer treatment, Bioorganic Chemistry 137 (2023) 106582 3. Design and synthesis of multivalent drug delivery system with CA IX inhibitors as ligands, Bioorganic & Medicinal Chemistry 93 (2023) 117456 4. Design, synthesis, and biological evaluation of BRD4 degraders, Bioorganic & Medicinal Chemistry 78 (2023) 117134 5. Design, synthesis, and biological evaluation of 4‑(1H‑1,2,3‑triazol‑1‑yl) benzamides as HSP90 inhibitors, Molecular Diversity (2023) 27:239–248 代表性论文 给药系统: 1. SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy, Journal of Controlled Release, 2021, 339, 297-306 2. A camptothecin-based albumin-binding prodrug enhances efficacy and safety in vivo, European Journal of Medicinal Chemistry, 2021, 226, 113851 3. An HSP90 inhibitor based fluorescent probe for selective tumor targeting, Dyes and Pigments, 2021, 196, 109783 4. A water-soluble probe with p-hydroxybenzyl quaternary ammonium linker for selective imaging in senescent cells, Analytica Chimica Acta, 2020, 133, 99-108 5. A Novel Multifunctional 2-Nitroinmidazole-based Bioreductive Linker and its Application in Hypoxia-Activated Prodrug, Bioorganic Chemistry, 2020, 101, 193975 6. Design, synthesis and biological evaluation of HSP90 inhibitor SN38 conjugates for targeted drug accumulation, Journal of Medicinal Chemistry, 2020, 53, 5421-5441 7. Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging, Journal of Materials Chemistry B, 2020, 8, 1878—1896 8. Enhanced cellular uptake efficiency of DCM probes or SN38 conjugating with phenylboronic acids, Bioorganic & Medicinal Chemistry, 2020, 28, 115377 9. Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro, Bioorganic & Medicinal Chemistry,2019, 27(7), 1405-1413 10. A series of camptothecin prodrugs exhibit HDAC inhibition activity, Bioorganic & Medicinal Chemistry, 2018, 26, 4706–4715 11. Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole, ACS Medicinal Chemistry Letters, 2017, 8 (7), 762–765 12. Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38, European Journal of Medicinal Chemisty, 2017, 132, 135-141 13. Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host–guest complexation of a pair of homopolymers, Journal of Materials Chemistry B, 2017, 5, 83 14. 10-Boronic acid substituted camptothecin as prodrug of SN-38, European Journal of Medicinal Chemistry, 2016, 116, 84-89 15. Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker, Bioconjugate Chemistry, 2016, 27(5), 1267-1275 16. Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins, Bioorganic & Medicinal Chemistry, 2004, 12, 4003-4008 17. Camptothecin derivative-loaded poly(caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide) nanoparticles and their biodistribution in mice, Journal of Controlled Release, 2004, 96, 135-148
药物化学: 1. Design, synthesis, and biological evaluation of Wee1 kinase degraders, European Journal of Medicinal Chemistry, 2022, 243, 114786 2. Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging, Dyes and Pigments, 2020, 178,108353 3. Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, European Journal of Medicinal Chemistry, 2019, 176,419-430 4. Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR, European Journal of Medicinal Chemistry, 2018, 158, 428-441 5. Design and synthesis of aryloxypropanolamine as b3-adrenergic receptor antagonist in cancer and lipolysis, European Journal of Medicinal Chemistry, 2018, 150, 757-770 6. Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors, European Journal of Medicinal Chemistry, 2015, 95, 127-135. 7. Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents, Bioorganic & Medicinal Chemistry, 2015, 23,1950-1962 8. Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1597-1599 9. The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase, Bioorganic & Medicinal Chemistry, 2013, 21, 6981-6995 10. Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs, European Journal of Medicinal Chemistry, 2013, 64, 613-620 11. The discovery of colchicine-SAHA hybrids as a new class of antitumor agents, Bioorganic & Medicinal Chemistry, 2013, 21, 3240-3244. 12. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents, European Journal of Medicinal Chemistry, 2013, 63, 746-757 13. Synthesis and biological evaluation of new homocamptothecin analogs, European Journal of Medicinal Chemistry, 2012, 54, 417-422. 14. Total Synthesis of Camptothecin and SN-38, The Journal of Organic Chemistry, 2012, 77(1), 713-717 15. Synthesis and Biological Evaluation of Piper Amide Analogues as HDAC Inhibitors, Bioorganic & Medicinal Chemistry Letters,2011, 21, 4844-4866 16. Design and synthesis of novel benzimidazole derivatives as inhibitors, Bioorganic & Medicinal Chemistry, 2010, 18, 5048-5055. 17. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo, Clinic Cancer Research, 2007, 13, 1298-1237. 18. Identification of 1-isopropylsulfonyl-2-amine benzimidazoles as a new class of inhibitors of hepatitis B virus, European Journal of Medicinal Chemistry, 2007, 42, 1358-1364. 19. Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives, Journal of Medicinal Chemistry, 2006, 49, 4790-4794. 20. Synthesis and antitumor activity of the hexacyclic camptothecin derivatives, Bioorganic & Medicinal Chemistry Letters,2005, 15, 3233-3236. 21. Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of Camptothecin, Bioorganic & Medicinal Chemistry Letters,2005, 15, 2003-2006. 荣誉及奖励 |