王镜

纵向项目

1. 国家自然科学基金面上项目，81872812，T细胞靶向稳定核酸脂质纳米粒用于体内产生白介素-6分泌功能缺失的嵌合抗原受体T细胞（CAR-T）研究，57万元，在研，第一参与人。

2. 国家自然科学基金面上项目，81570389，建立ApoE/ADAMTS-18双基因剔除小鼠模型研究金属蛋白酶ADAMTS-18抗动脉粥样硬化作用，在研，第二参与人。

3.  上海市科委科技项目，19ZR1416000，大区域病理图谱联合的深度学习及胃肠肿瘤早期诊断研究，在研，参与。

横向项目

1. 上海优卡迪生物医药科技有限公司，治疗重大疾病的项目技术服务，60万，在研，主持。

2. 上海优卡迪生物医药科技有限公司，嵌合抗原受体T细胞实体瘤原位给药效果评价， 15万，在研，主持。

3. 复旦大学附属华山医院，以香草酸受体亚型TRPV1为靶点的新型Capsaicin纳米探针的构建及其在心脑器官联合保护中的应用，8万，在研，主持。

4. 上海楷替生物医药科技有限公司, 生物医药材料和纳米制剂药属性和功能相关性的探索, 120万，在研，第二参与人   

发表文章

• 1. JingWang，XueyingLiu，YitingWang，LeiYu，HuiPeng，Jian-ZhongZhu*. Fe NPs and MWCNTs based electrode as FIA detector for determination of amino acids in hypothalamus microdialysis fluids. SENSORS AND ACTUATORS B-CHEMICAL. 2017;238;834-841

• 2. LinHan，YeXiao，MingxueFan，JingWang*，ZhiqiangYan，YitingWang*，LeiYu，HuiPeng，JianzhongZhu, Synthesis and biological evaluation of an anticancer drug delivery system: Poly(L-gamma-glutamyl-L-carbocisteine)-paclitaxel nanoconjugate. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.2017(81),113-119

• 3. LipengGao，XiaoZhao，JingWang*，YitingWang*，LeiYu，HuiPeng，JianzhongZhu. Multiple functionalized carbon quantum dots for targeting glioma and tissue imaging. OPTICAL MATERIALS. 2018(75),764-769

• 4. JingWang, QilongLi，JingE.Zhou，YitingWang*，LeiYu，HuiPeng，JianzhongZhu*. Synthesis, characterization and cells and tissues imaging of carbon quantum dots. OPTICAL MATERIALS. 2017(72),5-19

• 5. Zhang J, Shen H, Xu J, Liu L, Tan J, Li M, Xu N, Luo S, Wang J, Yang F, Tang J, Li Q, Wang Y, Yu L*, Yan Z*. Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by Dual Antifibrotic and Anti-inflammatory Activities. ACS Nano, 2020;14(5):6305-22.

• 6. Gao L, Yu J, Liu Y, Zhou J, Sun L, Wang J, Zhu J, Peng H, Lu W, Yu L, Yan Z*, Wang Y*. Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics. Theranostics, 2018, 7(20):4984-5000

• 7. Fan M, Li M, Gao L, Geng S, Wang J, Wang Y, Yan Z*, Yu L*. Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukaemia. J Hematol Oncol, 2017, 10(1): 151.

• 8. Jia Z, Gong Y, Pi Y, Liu X, Gao L, Kang L, Wang J, Yang F, Tang J, Lu W, Li Q, Zhang W, Yan Z*, Yu L*. pPB peptide-mediated siRNA-loaded stable nucleic acid lipid nanoparticles on targeting therapy of hepatic fibrosis. Mol Pharm, 2018, 15(1): 53-62

• 9. Fan M, Geng S, Liu Y, Wang J, Wang Y, Zhong J*, Yan Z*, Yu L. Nanocrystal technology as a strategy to improve drug bioavailability and antitumor efficacy for the cancer treatment. Current Pharmaceutical Design, 2018, 24(21): 2416-2424

• 10. Zhou JE, Yu J, Gao L, Sun L, Peng T, Wang J, Zhu J, Lu W, Zhang L, Yan Z*, Yu L*. iNGR-Modified Liposomes for Tumor Vascular Targeting and Tumor Tissue Penetrating Delivery in the Treatment of Glioblastoma. Mol Pharm, 2017, 14(5): 1811-1820.

• 11. Gao L, Wang H, Nan L, Peng T, Sun L, Zhou J, Xiao Y, Wang J, Sun J, Lu W, Zhang L, Yan Z*, Yu L, Wang Y*. Erythrocyte Membrane-Wrapped pH Sensitive Polymeric Nanoparticles for Non-Small Cell Lung Cancer Therapy. Bioconjug Chem, 2017, 28(10):2591-2598

• 12. Yu J, Sun L, Zhou J, Gao L, Nan L, Zhao S, Peng T, Han L, Wang J, Lu W, Zhang L, Wang Y, Yan Z*, Yu L*. Self-Assembled Tumor Penetrating Peptide Modified Poly (L-gamma-glutamylglutamine)-Paclitaxel Nanoparticles Based on Hydrophobic Interaction for Treatment of Glioblastoma. Bioconjug Chem, 2017, 28(11):2823-2831

• 13. Gao L, Han L, Ding X, Xu J, Wang J, Zhu J, Lu W, Sun J, Yu L, Yan Z*, Wang, Y*. An Effective Intracellular Delivery System of Monoclonal Antibody for Treatment of Tumor: Erythrocyte Membrane-coated Self-associated Antibody Nanoparticles. Nanotechnology, 2017, 28(33):335101.

• 14. Gao L, Gao L, Fan M, Li Q, Jin J, Wang J, Lu W, Yu L, Yan Z*, Wang Y*. Hydrotropic polymer-based paclitaxel-loaded self-assembled nanoparticles: preparation and biological evaluation. Rsc Advances, 2017, 7(53): 33248-33256.

• 15. Gao L, Zhou J, Yu J, Li Q, Liu X, Sun L, Peng T, Wang J, Zhu J, Sun J*, Lu W, Yu L, Yan Z*, Wang Y*. A Novel Gd-DTPA-conjugated Poly(L-gamma-glutamyl-glutamine)-paclitaxel Polymeric Delivery System for Tumor Theranostics. Sci Rep, 2017, 7(1): 3799.

• 16. Pi Y, Zhou J, Wang J, Zhong J, Zhang L, Wang Y, Yu L*, Yan Z*. Strategies of overcoming the physiological barriers for tumor-targeted nano-sized drug delivery systems. Curr Pharm Des, 2015, 21(42): 6236-6245.

• 17. Improved Sensing Membrane Immobilization for Enhanced Long-Term Stability of Iodide Ion-Selective Microelectrode, Chen, Yun; Zhang, Jian; Wang, Yi-Ting; Wang, Jing; Bao, Yan-Jie; Du, Wei-Jie; Li, Jun-Jun; Peng, Hui; Zhu, Jian-Zhong,Nanoscience and Nanotechnology Letters, Volume 5, June 2013.

• 18. Improved Enzyme Immobilization for Enhanced Bioelectrocatalytic Activity of Choline Sensor,Wang, Yiting; Yu, Lei; Zhu, Ziqiang; Wang, Jing; Bao, Yanjie; Du, Weijie; Li, Junjun; Peng, Hui; Zhu, Jianzhong,Nanoscience and Nanotechnology Letters, Volume 5, June 2013

• 19. Preparation of water soluble CdSe and CdSe/CdS quantum dots and their uses in imaging of cell and blood capillary. Yanjie Bao, Junjun Li, Yiting Wang, Lei Yu, Jing Wang, Weiji Du, Lei Lou, Ziqiang Zhu, Hui Peng,Jianzhong Zhu. Optical Materials 34 (2012) 1588–1592

• 20. A novel L-lactate sensor based on enzyme electrode modified with ZnO nanoparticles and multiwall carbon nanotubes. Y.T. Wang, L. Yu, J. Wang, L. Lou, W.J. Du, Z.Q. Zhu, H. Peng, J.Z. Zhu. Journal of Electroanalytical Chemistry 661 (2011) 8–12

• 21. Physicochemicalproperties and biocompatibility of a polymer-paclitaxelconjugate for cancertreatment. Yang D, Van S, Liu J, Wang J, Jiang X, Wang Y, Yu L.Int J Nanomedicine.2011;6:2557-66. Epub 2011 Oct 21.  

• 22. A review on the Self-report Tool of Aggression, Wang Jing, Han Xiuhua, Sun Lianrong. Psychological SciencePsychological Science, 2009, 32(05):1169-1171

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• 授权发明专利

• 1. 王镜, 俞磊, 赵潇, 肖晔, 董素珍, 闫志强, 王依婷, 朱建中, 彭晖. 用于生物成像和脑胶质瘤靶向的纳米粒子及制备方法和应用. 授权时间：2018.04.24, ZL201510032689.0

  2. 俞磊, 王华, 张磊涛, 南丽娟, 肖晔, 闫志强, 王镜, 王依婷, 朱建中. 用于抗肿瘤药物递送的小分子材料及制备方法和应用. 授权时间：2018.02.23, ZL201610124031.7

  3. 王依婷, 肖晔, 南丽娟, 赵潇, 王镜, 俞磊, 朱建中, 董素珍, 闫志强. 用于抗肿瘤药物递送的酸敏感高分子载体及制备方法和应用. 授权时间：2017.1.25, ZL201510051159.0

  4. 俞磊, 李奇龙, 周靖娥, 高礼鹏, 余静, 孙磊, 闫志强, 王镜, 朱建中, 王依婷. 一种光聚合水凝胶局部药物递送系统及制备方法和应用. 授权时间：2019.8.23. ZL 201610935556.9

  5. 王依婷, 丁晓铃, 汉琳, 孙磊, 闫志强, 朱建中, 王镜, 俞磊. 用于抗体药物递送的红细胞膜包裹的抗体纳米粒子及制备方法. 授权时间：2019.3.1. ZL 201610148434.5

  6. 王依婷, 高礼鹏, 周靖娥, 余静, 彭婷, 李奇龙, 闫志强, 王镜, 朱建中, 俞磊. 多功能高分子前药纳米递药系统及制备方法和用途. 授权时间：2019.11.1. ZL 201610917771.6

  7. 俞磊, 刘秧, 贾宗翔, 南丽娟, 赵世民, 王昊, 闫志强, 王镜, 朱建中, 王依婷. 一种MnO2包裹聚多巴胺的纳米颗粒及制备方法和应用. 授权时间：2019.11.5. ZL 201711008869.0

  8. 王依婷, 高礼鹏, 余静, 刘秧, 周靖娥, 孙磊, 闫志强, 王镜, 朱建中, 俞磊. 一种肿瘤靶向多功能纳米递药系统及制备方法和用途. 授权时间：2020.2.14. ZL 201710038827.5

  9. 俞磊, 孙磊, 周靖娥, 彭婷, 李奇龙, 南立娟, 高礼鹏, 闫志强, 王镜, 朱建中. 一种物理包裹的肿瘤靶向纳米递药系统及制备方法和应用. 授权时间：2020.5.12. ZL 201710136815.6

2018-2019年度华东师范大学大型精密仪器设备共享服务先进个人